Post #827: Yeah, this really is the vaccine I want

Source: Safety and immunogenicity of the Ad26.COV2.S COVID-19 vaccine candidate: interim results of a phase 1/2a, double-blind, randomized, placebo-controlled trial.  Jerry Sadoff, Mathieu Le Gars, Georgi Shukarev, et al.,

Four days ago, in Post #824 , I stated that the Johnson and Johnson (J and J) COVID-19 vaccine is the one I want to get.  That was based on my reading of the initial research findings on monkeys, and some oblique hints dropped by US public health officials.

Friday’s news strongly reinforces that conclusion.  J and J tested the vaccine on hundreds of healthy people, and 98% of them developed “neutralizing antibodies” four weeks after vaccination. You can see popular press reporting of this at these links (The Independent, Reuters), and can read the original research at this link (medRxiv, hit “download pdf” to see full research paper.)
Continue reading Post #827: Yeah, this really is the vaccine I want

Post #825: Have we stopped being stupid yet? Part III

  1. Source:  zippythepinhead.com  This image is copyright Bill Griffith, and is used without permission.  But with the notation that “Are we having fun yet??” in fact originates with Bill Griffith/Zippy the Pinhead, but has been so frequently copied that many people incorrectly believe the source is apocryphal.

 

 

 

I think by now you know the answer to this one.  Not even close.  Not even if it allows a few ignorant souls to put our children’s welfare at risk.

What set off this rant was the news, yesterday, that the Governor of Florida has identified a new fundamental freedom, the defense of which is crucial to the Nation.  And here, I am of course talking about the newly-identified “Right to Party”.  Continue reading Post #825: Have we stopped being stupid yet? Part III

Post #824: This is the vaccine I want

Source:  Figure 5 from:  Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature (2020). https://doi.org/10.1038/s41586-020-2607-z

I admit to being an unabashed fan of Johnson and Johnson (J and J).  That’s an informed opinion, having worked as a technical consultant to numerous Fortune 500 health care companies.  From what I could tell, in my limited perspective as a consultant, they were, with one possible exception, the best and the brightest of US health care manufacturers. 

And consummate business people.  I’m a fan, as I said.

And so, just to prep you for the conclusion here, if J and J thought that Moderna (the officially anointed US vaccine manufacturer) had some sort of amazingly effective and patented approach to producing vaccines, they’d have bought them already.  Or at least bid for them, up to what they believed the value the firm was worth.

To me, in this circumstance, the fact that J and J didn’t try to buy them speaks volumes.  It tells me that J and J thought they’d do better, relying only on expertise within the J and J family. Not that this is some point-of-pride thing, but merely adhering to a least-cost make-or-buy decision.  Just the way that is taught in business textbooks.

Understanding that I’m an economist, and not an expert on the science, let me try to read the tea leaves, on what’s now being reported on the J and J vaccine. Continue reading Post #824: This is the vaccine I want

Post #822: CDC: Just kidding, we take it all back

Source:  CDC

Just this morning, I posted the new CDC guidance to citizens on COVID-19 (Post #820).  The CDC finally mentioned aerosol (airborne) transmission of the disease.

Half-jokingly, I said:

In particular, I would not be surprised to see this language disappear, once those in power do realize the implications.  Hence the snapshot, above.

Well, as of about 1 PM, the A-words have been tossed down the memory hole.  I’m not holding my breath, waiting for them to return.

So, for one bright shining moment, CDC told the entire story to Americans.  Until somebody got wind of it, and put a stop to that.  Sometimes it’s hard to believe what a total crap show our Federal government has become.

In memorium.

Source:  CDC, but long longer posted.

Post #820: The CDC finally says the A-words.

Source:  US CDC. I added the red lines.

The A-words would be aerosol and airborne.  The difference being that, up to this time, the CDC had only said COVID-19 was spread by droplets.  Droplets are (conventionally) larger than 5 microns, rapidly fall out of the air (so-called “ballistic trajectory”),  and are the basis for our 6′ social distancing rule.  By contrast, aerosols are small (under 5 microns), can hang in the air for a long time, can travel far more than 6′, and can be inhaled.

The news here isn’t that aerosol transmission matters.  The news is that, as of last Friday, the CDC is (finally) explicitly saying that.  And that, in turn, has a lot of implications for Federal, state, and local policies for dealing with COVID-19.

You can read some news writeups at MSN, or CNN.  Someone in those organizations must have been keeping an eye out for this, because I don’t see this being reported elsewhere.  Yet. Continue reading Post #820: The CDC finally says the A-words.

Post #818: Well, turns out, this *is* as good as it gets.

Three days ago, the head of the US CDC said, more-or-less, that you’re going to get more protection from wearing a mask than you are from the forthcoming US vaccine.  He’s had to recant, publicly, since then.  But my guess is the he got it right the first time.

I summarized that in Post #815, What if this is as good as it gets?  With the title being my take on that testimony.  We’ve been expecting a vaccine to make a radical change in the situation.  But, taken at face value, the US CDC director basically just told us, that’s not going to happen.  Presumably, the implication of what he said is that it’ll do no more than mask wearing and social distancing have done.

Today I stumbled across a recent interview with Dr. Fauci where he said that if we adhere to all the current public health measures, and we get a “good” vaccine, we might be able to return to normalcy as early as the end of 2021.  Apparently, he’s been saying 2021 for some time.  This is the first time I’d seen it stated as the end of 2021.  And seen that conditional on having a “good” vaccine.

So, twice in the last couple of days, responsible public health leaders have told us that this is about as good as it gets, for the time being.  Vaccines really won’t alter the situation in any material way, for quite some time.  Even with a “good” vaccine, the situation we are in right now — with the shutdowns and social distancing and all of that — that’s as good as it gets, until at least the end of 2021.  And that’s only projected to end if we have a “good” vaccine, and everybody adheres to the other public health measures like social distancing and mask use.

At this point, I feel like I’ve been sleepwalking through this.  I need slap myself across the face, wake up, and start listening to the people who know what they’re talking about, and plan accordingly. 

The smartest people in the room are trying to tell us that we’re going to be in this semi-lockdown, socially-distanced, mask-wearing limbo for … a year or years to come.  Vaccine or no vaccine.

And now that I’m waking up, I realize just how many things I’d let slide because I unconsciously assumed that there was a chance that we could return to normalcy soon.  Particularly with numerous vaccines on the way.  No sense in doing things that incur a risk of COVID-19 infection if US society is likely to be COVID-free in the near future.

Should I list a few?  I’ve been slacking off on exercise, thinking, well, I’ll be able to get back to the gym soon enough.  Nope.  No I won’t.  So I’ve been putting on weight accordingly, but you know, that’ll come off when I can get back to the gym three days a week.  Nope, that’s not going happen any time soon.  I’ve put off seeing the doctor, figuring, it can wait until things are back to normal.  No sense being around a lot of sick people during a pandemic.  I’ve put off a major home repair because I don’t want workmen in the house, figuring things won’t have rotted out completely by the time we’re over this COVID thing.  Again, wrong, wrong, wrong.  And so on.

So I think I finally am getting my mind around this.  This really is as good as it gets.  For quite some time, anyway.  That’s what the smartest people in the business are telling us.  If you try to live your life in a reality-based fashion, plan accordingly.

 

Post #817: Vaccine and sins of omission.

I’ve had a series of posts arguing that Russia (and now the China) are doing the right thing by deploying their vaccines before they know their effectiveness.  That was stated most recently in Post #814.  Both countries are already providing those vaccines to high-risk populations such as health care workers, before they know how effective the vaccines are (or aren’t) in preventing (or lessening severity of) COVID-19 infection.

Today’s twist is that they are also winning allies and gaining international influence by supplying vaccines, now, to other countries that need them.  That’s written up in this Washington Post article.  So not only are they ahead in their own country, but they are gaining influence around the world by being first-to-market in a number of countries that need help right now.  (And, in an odd twist, they’ve decided to pool some efforts on their vaccines. )

In this post, I’m going to review the logic behind this one last time, and then do the grade-school arithmetic that validates that logic.  Something that, apparently, neither our elected officials nor our public health bureaucracy seems willing or able to do.  Or at least, to admit to doing, in public.

My best guess, using some quite conservative estimates, is that providing 10 million doses of vaccine now, instead of six months from now, would save just under 10,000 hospitalizations (worth about a quarter-billion dollars), and about 2800 lives.  This doesn’t even count other costs saved, such costs saved by avoidance permanent organ damage from COVID-19, or economic losses from work or school time not missed due to COVID-19 illness and quarantine.    Not only would the avoided hospital costs more than pay for the vaccine itself, these numbers are vastly higher than any plausible health or economic damage from any as-yet-undiscovered rare side effects of the vaccines.

Details follow.
Continue reading Post #817: Vaccine and sins of omission.

Post #816: We actually did have a rational, national plan for mask use?

Source:  The Daily Beast, from an article on the demonization of masks in Trump world.

Yep, we did.  We had a national mask initiative in the works.  It’s just that the President killed it.  As you can read in this famously not-liberal publication, Business Insider.  You can also see the same information buried inside this Washington Post article.  You can also see that the bare bones of this story were reported back in April, when the mask initiative was killed.

I just wanted to document this here, as it really didn’t get much play on its own and it’s already slipping out of the news. Continue reading Post #816: We actually did have a rational, national plan for mask use?

Post #815: What if this is as good as it gets?

Source:  Immunogenicity and protective efficacy of influenza vaccination
Claude Hannouna, Francoise Megas,  James Piercy,  Virus Research 103 (2004) 133–138.

The importance of this graph will be clear about five paragraphs down.

At this point, with the Phase III trials of coronavirus vaccines well underway, even if they don’t have enough “statistical power” to do the formal statistical test, our public health bureaucracy ought to have a fairly good indication of how things are shaping up.

I’ve been waiting for any US public health leader to start leaking information on the likely effectiveness of the coronavirus vaccines.   Informally tossing some numbers out there, to get us prepped for the eventual formal announcement.

We just got our first indication today.  And, although the CDC Director broke the news gently, and indirectly, and with spin, if you paid attention, the news was clearly not good. Continue reading Post #815: What if this is as good as it gets?

Post #814: COVID-19 vaccines. The Chinese get it, the Russians get it. We don’t get it.

In Post #777 (and earlier), I talked about why the Russian strategy of early use of their vaccine made good sense.  And now, it turns out that the Chinese are doing the same thing as the Russians.  They just didn’t brag about it, the way the Russians did.  I guess I am unsurprised that the Chinese are doing the rational thing here.

In both cases, they are taking vaccines that have passed safety trials, but have not yet completed trials showing whether or not they work, and they are using them right now, for high-risk populations such as health care workers.

This is so rational, and so logical.  And yet, apparently so beyond the grasp of our government.  Either our elected leaders or our professional bureaucracy. Continue reading Post #814: COVID-19 vaccines. The Chinese get it, the Russians get it. We don’t get it.